Programming Bugs: Microbiota and the Developmental Origins of Brain Health and Disease | Semantic Scholar (2024)

This narrative review focuses on the importance of the GI microbiota and the impact of nutrition on MGB axis during the immune system and brain developmental period in early postnatal life of infants.

In this view, the relative success of “probiotic” bacteria is due to their temporary immune system activation of the gut–brain axis, in turn suggesting a potential mechanism for the placebo effect.

Emerging and exciting evidence of intricate and crucial connections between the gut microbiota and the brain involving multiple biological systems, and possible contributions by the Gut microbiota to neurological disorders are discussed.

Future studies will focus on understanding the mechanisms underlying the microbiota-gut-brain axis and attempt to elucidate microbial-based intervention and therapeutic strategies for neuropsychiatric disorders.

Early life represents an opportunity to implement clinical practices that promote the optimal seeding and feeding of the gut microbial ecosystem, including reducing nonemergent cesarean deliveries, avoiding the use of antibiotics, and promoting exclusive breastfeeding.

This review systematically review the role of maternal microbiomes in different gestational complications, and elucidate the function and mechanism of maternal microbes in the neural development and immune system of offspring to provide a clear knowledge framework or potential research direction for researchers in related fields.

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The present review summarizes the impact of cesarean birth on the gut microbiome and the health status of the developing infant and discusses possible preventative and restorative strategies to compensate for early-life microbial perturbations.

The vagin*l microbiota is identified as a novel factor by which maternal stress may contribute to reprogramming of the developing brain that may predispose individuals to neurodevelopmental disorders.

The microbiome needs to be incorporated into studies that quantify interactions among genotype, environment, and the microbiome in order to predict human disease susceptibility, and to identify human genetic variants associated with microbiome phenotypes.

It is shown, in a primate model, that maternal diet during pregnancy affects the offspring’s microbiome, and that dietary intervention after weaning only partially reverses this effect.

Current scientific evidence does not support the existence of microbiomes within the healthy fetal milieu, which has implications for the development of clinical practices that prevent microbiome perturbations after birth and the establishment of future research priorities.

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